HitPredict

Interactor 1: PRKRA (O75569)
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)
Gene: PRKRA

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33731348
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 313 Hs			1 595
+	Hs
		369676 TRBP2_HUMAN (18-313): 1.34e-81: 253: 41.08		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369499 ILF3_HUMAN (7-290): 1.14e-53: 190: 13.71		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368966 E2AK2_HUMAN (36-311): 2.71e-51: 179: 18.50		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370104 DGCR8_HUMAN (1-276): 1.44e-44: 163: 19.42		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		269821 PRKRA_HUMAN (1-313): 1.21e-119: 348: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		370530 STAU2_HUMAN (33-309): 3.5e-30: 121: 18.79		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		1075617 TRBP2_HUMAN (18-313): 1.34e-81: 253: 41.08		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		322053 STAU1_HUMAN (82-309): 9.84e-10: 61.5: 17.54		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		585515 E2AK2_HUMAN (36-311): 2.71e-51: 179: 18.50		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1264619 DGCR8_HUMAN (1-276): 1.44e-44: 163: 19.42		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269425 STRBP_HUMAN (5-176): 5.53e-30: 121: 15.09		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269728 STAU2_HUMAN (33-309): 3.5e-30: 121: 18.79		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		877332 DSRAD_HUMAN (90-306): 2.7e-29: 120: 16.51		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		740513 ILF3_HUMAN (7-290): 1.14e-53: 190: 13.71		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		1264701 DGCR8_HUMAN (1-276): 1.44e-44: 163: 19.42		NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12
+	Hs
		377621 STRBP_HUMAN (5-176): 5.53e-30: 121: 15.09		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		611514 STAU2_HUMAN (33-309): 3.5e-30: 121: 18.79		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		320146 STAU1_HUMAN (82-309): 9.84e-10: 61.5: 17.54		ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86
+	Hs
		322119 STAU1_HUMAN (82-309): 9.84e-10: 61.5: 17.54		ERR1_HUMAN (123-547): 6.94e-103: 319: 34.04
+	Hs
		487268 DSRAD_HUMAN (90-306): 2.7e-29: 120: 16.51		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16