Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6
Interactor 2: DKK1 (O94907)
Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)
Gene: DKK1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 0.60 | 0.754 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 27322059, 33961781, 11448771, 21984209, 21944579 |
| Identification Methods | affinity chromatography technology, pull down, amplified luminescent proximity homogeneous assay, bio-layer interferometry, molecular sieving, x-ray crystallography, dynamic light scattering, light scattering, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0031901 - early endosome membrane GO:0060070 - canonical Wnt signaling pathway GO:0090244 - Wnt signaling pathway involved in somitogenesis |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
