HitPredict

Interactor 1: UBP2 (O75604)
Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
Gene: USP2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	29576527, 33141564, 33067239, 16196087, 20516210, 23287719, 25527291, 26588485, 26876099, 28319114, 27436899, 28536428, 27613037, 27501351, 29449607, 25764917, 24361330, 16905103, 20622874, 19373254 and 2 others more... 23211065, 20940148
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, unspecified method
Interaction Type	direct interaction, physical association, association, deubiquitination reaction

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 605 Hs			1 685
+	Hs
		476545 UBP21_HUMAN (72-604): 7.31e-131: 396: 33.86		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475440 UBP8_HUMAN (61-602): 1.91e-124: 395: 28.81		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476579 UBP22_HUMAN (232-599): 1.07e-113: 351: 30.12		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475932 U17L2_HUMAN (193-604): 2.62e-112: 347: 26.08		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		64200 UBP27_HUMAN (198-599): 1.23e-111: 342: 27.79		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476400 UBP42_HUMAN (165-599): 1.9e-101: 337: 23.93		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476493 UBP36_HUMAN (162-598): 2.8e-102: 336: 27.15		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475566 UBP46_HUMAN (243-600): 1.24e-108: 332: 24.33		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477538 NOT_DROME (227-598): 5.43e-110: 340: 30.26		UBIQP_DROME (1-610): 0: 752: 99.84
+	At
		1210479 UBP15_ARATH (86-604): 1.47e-111: 357: 20.22		UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80
+	Rn
		1137288 UBP2_RAT (1-605): 0: 620: 89.32		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		271114 UBP2_HUMAN (1-605): 0: 636: 100.00		Q5U5U6_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Sc
		477294 UBP5_YEAST (57-598): 2.15e-107: 343: 23.54		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		1092065 UBP15_ARATH (86-604): 1.47e-111: 357: 20.22		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		476865 UBP8_MOUSE (169-602): 1.41e-122: 389: 34.10		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		398134 UBP21_HUMAN (72-604): 7.31e-131: 396: 33.86		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		924201 UBP36_HUMAN (162-598): 2.8e-102: 336: 27.15		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		476741 UBP46_MOUSE (243-600): 1.24e-108: 332: 24.33		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		477008 UBP12_MOUSE (266-600): 2.34e-108: 332: 26.50		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		474982 UBP46_HUMAN (243-600): 1.24e-108: 332: 24.33		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70