HitPredict

Interactor 1: UBP2 (O75604)
Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
Gene: USP2

Interactor 2: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	36880596
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding GO:0032922 - circadian regulation of gene expression GO:0043153 - entrainment of circadian clock by photoperiod and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 605 Hs			1 882
+	Hs
		668687 UBP10_HUMAN (94-600): 1.5e-102: 330: 18.96		PML_HUMAN (1-882): 0: 902: 100.00
+	Hs
		668533 UBP11_HUMAN (453-605): 5.32e-29: 124: 37.98		PML_HUMAN (1-882): 0: 902: 100.00
+	Hs
		271187 UBP2_HUMAN (1-605): 0: 636: 100.00		TRIM8_HUMAN (51-553): 2.61e-68: 239: 14.68
+	Hs
		271189 UBP2_HUMAN (1-605): 0: 636: 100.00		TRIM5_HUMAN (44-459): 3.78e-58: 209: 12.33
+	Hs
		271195 UBP2_HUMAN (1-605): 0: 636: 100.00		TRI39_HUMAN (48-434): 3.1e-57: 207: 11.37
+	Hs
		271032 UBP2_HUMAN (1-605): 0: 636: 100.00		RO52_HUMAN (44-414): 8.03e-56: 202: 13.46
+	Hs
		271214 UBP2_HUMAN (1-605): 0: 636: 100.00		TRIM1_HUMAN (48-412): 7.57e-53: 199: 14.67
+	Hs
		271128 UBP2_HUMAN (1-605): 0: 636: 100.00		TRI46_HUMAN (88-383): 3.63e-43: 170: 20.53
+	Hs
		1318357 UBP21_HUMAN (72-604): 7.31e-131: 396: 33.86		TRIM8_HUMAN (51-553): 2.61e-68: 239: 14.68
+	Hs
		1318717 UBP21_HUMAN (72-604): 7.31e-131: 396: 33.86		TRIM5_HUMAN (44-459): 3.78e-58: 209: 12.33
+	Hs
		64204 UBP27_HUMAN (198-599): 1.23e-111: 342: 27.79		TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97
+	Hs
		1029962 UBP36_HUMAN (162-598): 2.8e-102: 336: 27.15		TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97
+	Hs
		1121194 UBP39_HUMAN (57-600): 3.42e-104: 327: 19.75		TRIM8_HUMAN (51-553): 2.61e-68: 239: 14.68
+	Hs
		1121195 UBP39_HUMAN (57-600): 3.42e-104: 327: 19.75		TRIM5_HUMAN (44-459): 3.78e-58: 209: 12.33
+	Hs
		1121201 UBP39_HUMAN (57-600): 3.42e-104: 327: 19.75		TRI39_HUMAN (48-434): 3.1e-57: 207: 11.37
+	Hs
		1052655 UBP10_HUMAN (94-600): 1.5e-102: 330: 18.96		TRI25_HUMAN (42-366): 2.13e-54: 201: 16.67
+	Hs
		1019375 UBP36_HUMAN (162-598): 2.8e-102: 336: 27.15		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		1052677 UBP39_HUMAN (57-600): 3.42e-104: 327: 19.75		TRI25_HUMAN (42-366): 2.13e-54: 201: 16.67
+	Hs
		1019313 UBP39_HUMAN (57-600): 3.42e-104: 327: 19.75		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		164365 UBP11_HUMAN (453-605): 5.32e-29: 124: 37.98		TRI66_HUMAN (29-540): 6.56e-63: 233: 14.31