HitPredict

Interactor 1: UBP2 (O75604)
Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
Gene: USP2

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	22179575, 22659130
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 605 Hs			1 671
+	Hs
		201145 UBP2_HUMAN (1-605): 0: 636: 100.00		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		1038334 UBP21_HUMAN (72-604): 7.31e-131: 396: 33.86		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	Hs
		64205 UBP27_HUMAN (198-599): 1.23e-111: 342: 27.79		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	Hs
		201251 UBP8_HUMAN (61-602): 1.91e-124: 395: 28.81		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		1038344 UBP15_HUMAN (451-597): 1.6e-28: 123: 43.92		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	Hs
		1024324 UBP4_HUMAN (447-597): 2.22e-28: 122: 42.76		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	Hs
		201481 UBP15_HUMAN (451-597): 1.6e-28: 123: 43.92		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		201321 UBP4_HUMAN (447-597): 2.22e-28: 122: 42.76		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		201151 UBP19_HUMAN (454-602): 3.28e-23: 107: 39.62		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		411649 UBP11_HUMAN (453-605): 5.32e-29: 124: 37.98		LCK_HUMAN (23-289): 1.31e-27: 119: 31.87