HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	26831064, 22990118
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2136 Hs			1 1863
+	Hs
		272257 U520_HUMAN (1-2136): 0: 1844: 100.00		BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98
+	Hs
		272270 U520_HUMAN (1-2136): 0: 1844: 100.00		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		571337 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749648 DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749736 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749832 DDX23_HUMAN (1241-1748): 1.71e-87: 307: 14.36		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749727 PRP16_HUMAN (1317-1920): 4.33e-65: 246: 11.76		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		224842 DHX16_HUMAN (1094-2008): 1.27e-67: 252: 11.11		TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54
+	Hs
		571586 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		1271648 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30