HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2136 Hs			1 768
+	Hs
		272129 U520_HUMAN (1-2136): 0: 1844: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		272127 U520_HUMAN (1-2136): 0: 1844: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		272230 U520_HUMAN (1-2136): 0: 1844: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1042022 ASCC3_HUMAN (56-2134): 0: 1449: 38.34		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		571443 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1207268 Q8BTS0_MOUSE (1241-1718): 2.78e-108: 362: 12.47		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Hs
		1042199 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		786944 MTREX_HUMAN (1287-2037): 2.62e-101: 354: 18.12		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041574 DHX8_HUMAN (1313-1903): 1.71e-65: 247: 11.81		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042185 PRP16_HUMAN (1317-1920): 4.33e-65: 246: 11.76		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		571444 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		571445 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043492 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		571441 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041127 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		786943 MTREX_HUMAN (1287-2037): 2.62e-101: 354: 18.12		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		571442 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1041422 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		571542 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		CUL5_HUMAN (25-768): 0: 597: 23.77