HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28561026
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~TIP49
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2136 Hs			1 456
+	Hs
		272312 U520_HUMAN (1-2136): 0: 1844: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1204711 DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1204710 DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sp
		143168 YE02_SCHPO (1285-1736): 1.23e-86: 310: 21.71		RUVB1_SCHPO (1-456): 0: 671: 69.96
+	Sc
		810959 MTR4_YEAST (1270-1848): 1.11e-94: 335: 19.41		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Sp
		143083 YE02_SCHPO (1285-1736): 1.23e-86: 310: 21.71		RUVB2_SCHPO (1-455): 0: 639: 42.45