HitPredict

Interactor 1: A0A0C4DG49 (A0A0C4DG49)
PVR cell adhesion molecule (Poliovirus receptor, isoform CRA_c)
Gene: PVR

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	32900848
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0050862 - positive regulation of T cell receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 236
+	Hs
		545090 PVR_HUMAN (1-417): 4.07e-81: 257: 99.76		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887918 NECT2_HUMAN (25-333): 2.13e-70: 232: 52.80		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887960 NECT3_HUMAN (26-389): 1.35e-68: 228: 24.20		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887951 CADM1_HUMAN (34-360): 9.6e-61: 205: 21.04		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		602285 NECT3_HUMAN (26-389): 1.35e-68: 228: 24.20		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		887903 CADM4_HUMAN (1-395): 8.48e-61: 203: 19.30		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		888000 ROBO1_HUMAN (212-415): 3.98e-22: 101: 11.42		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		602297 ROBO1_HUMAN (212-415): 3.98e-22: 101: 11.42		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		1199563 TITIN_HUMAN (12-416): 2.67e-09: 61.5: 8.16		TSN33_HUMAN (9-233): 7.63e-51: 168: 22.78
+	Dm
		52381 A1Z7J1_DROME (28-344): 1.44e-14: 77.9: 16.18		Q7KJ73_DROME (3-234): 3.84e-44: 149: 21.37