HitPredict

Interactor 1: KS6A4 (O75676)
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
Gene: RPS6KA4

Interactor 2: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 418
+	Hs
		270422 KS6A5_HUMAN (2-772): 0: 765: 59.38		HS904_HUMAN (1-418): 0: 547: 100.00
+	Hs
		272843 KS6A4_HUMAN (1-772): 0: 787: 100.00		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		850666 KS6A3_HUMAN (1-740): 0: 703: 41.21		H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81
+	Hs
		1073431 KS6A1_HUMAN (3-739): 0: 701: 40.79		H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81
+	Hs
		272844 KS6A4_HUMAN (1-772): 0: 787: 100.00		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		270363 KS6A5_HUMAN (2-772): 0: 765: 59.38		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		270364 KS6A5_HUMAN (2-772): 0: 765: 59.38		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		272876 KS6A4_HUMAN (1-772): 0: 787: 100.00		H90B4_HUMAN (112-275): 1.78e-26: 112: 42.42
+	Hs
		431672 KS6A3_HUMAN (1-740): 0: 703: 41.21		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		431876 KS6A1_HUMAN (3-739): 0: 701: 40.79		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438011 KS6A3_HUMAN (1-740): 0: 703: 41.21		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		438193 KS6A1_HUMAN (3-739): 0: 701: 40.79		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		432343 KS6A6_HUMAN (2-740): 0: 680: 40.81		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438601 KS6A6_HUMAN (2-740): 0: 680: 40.81		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		431573 AKT2_HUMAN (322-741): 4.23e-120: 371: 21.71		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Mm
		432411 AKT1_MOUSE (402-742): 1.35e-120: 372: 25.42		HS90A_MOUSE (96-271): 1.07e-44: 167: 50.85
+	Rn
		812703 AKT1_RAT (402-742): 1.21e-120: 372: 25.42		HS90A_RAT (96-271): 1.02e-44: 167: 50.85
+	Bt
		964601 AKT1_BOVIN (402-742): 1.19e-121: 375: 25.71		HS90B_BOVIN (96-256): 4.94e-41: 156: 51.85
+	Mm
		513660 AKT1_MOUSE (402-742): 1.35e-120: 372: 25.42		HS90B_MOUSE (96-256): 4.94e-41: 156: 51.85
+	Hs
		437928 AKT2_HUMAN (322-741): 4.23e-120: 371: 21.71		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85