HitPredict

Interactor 1: ADAP1 (O75689)
Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25)
Gene: ADAP1

Interactor 2: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15923660
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arf~ArfGap, Arf~PH
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 175
+	Hs
		574718 SMAP2_HUMAN (3-325): 5.56e-72: 232: 22.53		ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74
+	Hs
		913022 ARAP2_HUMAN (10-357): 2.89e-70: 241: 19.83		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		950579 AGAP1_HUMAN (2-239): 6.94e-68: 231: 22.08		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		950582 GIT1_HUMAN (13-333): 2.47e-65: 222: 17.67		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		897390 SMAP2_HUMAN (3-325): 5.56e-72: 232: 22.53		ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54
+	Hs
		913191 AGAP1_HUMAN (2-239): 6.94e-68: 231: 22.08		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		913052 AGAP3_HUMAN (2-250): 7e-66: 226: 23.11		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		913202 GIT1_HUMAN (13-333): 2.47e-65: 222: 17.67		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		912911 ACAP2_HUMAN (4-247): 4.67e-63: 216: 23.81		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		950547 AGAP2_HUMAN (2-258): 5.07e-58: 205: 22.01		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Dm
		185486 GIT_DROME (19-317): 1.88e-58: 203: 16.36		O18332_DROME (1-175): 1.51e-66: 203: 20.56
+	At
		285978 AGD7_ARATH (6-287): 1.81e-61: 205: 18.13		ARF2B_ARATH (2-173): 7.78e-65: 198: 70.93
+	Hs
		912985 SMAP1_HUMAN (1-329): 3.18e-57: 195: 20.92		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		897381 SMAP1_HUMAN (1-329): 3.18e-57: 195: 20.92		ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54
+	Hs
		912909 ACAP1_HUMAN (9-124): 3.84e-45: 167: 38.98		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00