HitPredict

Interactor 1: RENR (O75787)
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
Gene: ATP6AP2

Interactor 2: SPB8 (P50452)
Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)
Gene: SERPINB8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 350 Hs			1 374
+	Hs
		275133 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		SPB13_HUMAN (1-374): 2.59e-155: 443: 39.03
+	Hs
		274959 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		SPB4_HUMAN (1-374): 3.16e-153: 438: 44.64
+	Hs
		274941 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		SPB3_HUMAN (1-374): 7.84e-152: 435: 43.62
+	Hs
		271844 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		SPB7_HUMAN (1-374): 1.65e-144: 416: 36.36
+	Hs
		274889 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		AACT_HUMAN (4-374): 7.5e-141: 408: 33.25
+	Hs
		275051 RENR_HUMAN (1-350): 1.38e-167: 472: 100.00		SPA12_HUMAN (3-374): 4.99e-52: 180: 29.71