Interactor 1: RENR (O75787)
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
Gene: ATP6AP2

Interactor 2: VAS1 (Q15904)
V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)
Gene: ATP6AP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.950

The method score is based on:

Property Details
Experiments 29127204, 35271311, 26186194, 26496610, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ac45-VOA1_TM~Renin_r, Renin_r~VAS1_LD
Common GO terms GO:0000139 - Golgi membrane
GO:0005765 - lysosomal membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0007035 - vacuolar acidification
and 12 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 350
Hs

1 470
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024