HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9872323
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 1130
+	Hs
		337293 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ABL1_HUMAN (1-1130): 0: 984: 100.00
+	Hs
		337384 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ABL2_HUMAN (10-1130): 0: 775: 52.62
+	Hs
		411573 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		337329 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		411545 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		412071 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		337307 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		411552 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		YES_HUMAN (5-510): 3.73e-179: 537: 39.42
+	Hs
		411648 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		411544 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		411559 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		HCK_HUMAN (9-508): 5.18e-175: 526: 38.79
+	Hs
		337315 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		HCK_HUMAN (9-508): 5.18e-175: 526: 38.79
+	Hs
		433653 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		411553 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		846446 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		BLK_HUMAN (9-508): 4.18e-165: 499: 38.33
+	Hs
		337440 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		BTK_HUMAN (5-501): 5.05e-156: 481: 36.56
+	Hs
		788974 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		TEC_HUMAN (40-502): 5.28e-154: 475: 36.71
+	Hs
		411626 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		CSK_HUMAN (61-500): 1.81e-155: 472: 37.72
+	Hs
		782751 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		CSK_HUMAN (61-500): 1.81e-155: 472: 37.72