HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	25402006, 24658140, 22973453, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, pull down, ubiquitin reconstruction, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1210
+	Hs
		338144 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337769 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338084 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337294 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		275197 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		275161 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		846473 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		411729 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		275172 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		383699 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383528 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		601856 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		411594 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		411611 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		275178 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		411688 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		111146 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		411633 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		411632 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59
+	Mm
		411920 LCK_MOUSE (3-136): 1.79e-53: 184: 34.46		ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00