HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1255
+	Hs
		383699 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383528 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		337300 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		275197 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		275158 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		846473 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		411729 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		275172 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		338144 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		337769 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338084 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		337294 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		601856 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		411594 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		337346 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		411611 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06
+	Hs
		411688 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07
+	Hs
		411720 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FAK2_HUMAN (724-977): 3.75e-53: 205: 39.76
+	Hs
		111146 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		I6L996_HUMAN (706-984): 3.35e-54: 204: 39.07
+	Hs
		337349 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47