HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9857184
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0043408 - regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 972
+	Mm
		292680 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		CSF1R_MOUSE (1-972): 0: 726: 74.57
+	Mm
		452188 PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81		CSF1R_MOUSE (1-972): 0: 726: 74.57
+	Hs
		275165 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		499249 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		411567 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		337322 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		499244 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		337317 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		738179 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		452370 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		411619 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		337376 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		738170 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Mm
		1141452 PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81		MERTK_MOUSE (79-922): 2.45e-136: 436: 21.26
+	Mm
		292679 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		KIT_MOUSE (9-293): 5.75e-23: 107: 13.08
+	Hs
		411613 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		UFO_HUMAN (1-308): 2.37e-23: 108: 14.49
+	Hs
		507897 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		674354 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		UFO_HUMAN (1-308): 2.37e-23: 108: 14.49
+	Hs
		607907 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71
+	Rn
		499160 PLCG1_RAT (24-328): 1.2e-33: 133: 15.79		FGFR1_RAT (32-209): 1.21e-24: 112: 14.56