HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 976
+	Hs
		499249 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		411567 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		337322 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499244 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		KIT_HUMAN (1-976): 0: 807: 100.00
+	Mm
		292679 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		KIT_MOUSE (1-975): 0: 773: 79.63
+	Hs
		337317 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		452370 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Mm
		404014 PLCG1_MOUSE (24-328): 1.03e-33: 133: 15.79		PGFRB_MOUSE (14-974): 0: 597: 29.51
+	Hs
		738179 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		411619 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		337376 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		738170 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Dm
		112243 CRK_DROME (48-329): 5.5e-47: 161: 18.88		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Mm
		292680 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Hs
		275162 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		607907 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21
+	Hs
		507897 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Rn
		499160 PLCG1_RAT (24-328): 1.2e-33: 133: 15.79		FGFR1_RAT (4-235): 6.64e-22: 104: 12.91
+	Mm
		452188 PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Mm
		729415 PLCG1_MOUSE (24-328): 1.03e-33: 133: 15.79		VGFR2_MOUSE (3-106): 2.04e-12: 73.6: 13.16