HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~SH2, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1271
+	Hs
		506538 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		337325 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		506541 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Mm
		1144835 CRK_MOUSE (46-330): 9.28e-35: 130: 18.87		BCR_MOUSE (1-1271): 0: 941: 93.79
+	Hs
		337453 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ABR_HUMAN (419-1271): 0: 567: 66.47
+	Hs
		411673 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FGD1_HUMAN (162-971): 1.22e-77: 279: 13.57
+	Hs
		411580 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		337333 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		802581 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49
+	Hs
		224698 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		KALRN_HUMAN (457-1087): 1.21e-57: 222: 14.20
+	Hs
		548634 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		548657 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		279830 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72
+	Hs
		164109 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		ARHGA_HUMAN (492-759): 1.03e-69: 259: 25.93
+	Hs
		411981 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		412357 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		ECT2_HUMAN (335-923): 3.96e-71: 259: 17.07
+	Hs
		224699 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		KALRN_HUMAN (457-1087): 1.21e-57: 222: 14.20
+	Hs
		411755 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		RHG21_HUMAN (1049-1216): 3.06e-23: 109: 40.00
+	Hs
		69205 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		A9UF07_HUMAN (690-1072): 3.04e-27: 122: 60.83
+	Ce
		220207 SRC2_CAEEL (224-326): 6.19e-18: 86.4: 19.05		TG325_CAEEL (1039-1212): 9.19e-24: 110: 37.93