HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1342
+	Hs
		601856 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		411594 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		275197 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		846473 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		411729 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		275161 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		275158 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383699 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383528 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337300 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338144 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337769 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338084 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337294 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		275157 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		337293 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		411611 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		411720 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FAK2_HUMAN (673-1201): 9.77e-104: 355: 25.96
+	Hs
		411688 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		111146 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19