HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	25814554, 12496419, unassigned1126
Identification Methods	two hybrid, biochemical, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 906
+	Hs
		610303 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		411595 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		337348 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		69201 A9UF07_HUMAN (4-134): 2.33e-49: 179: 36.23		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610281 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		292681 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		411917 LCK_MOUSE (3-136): 1.79e-53: 184: 34.46		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		337618 ABL1_MOUSE (4-134): 8.86e-51: 182: 36.23		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610604 PLCG1_MOUSE (24-328): 1.03e-33: 133: 15.79		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		275194 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		292684 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Hs
		411703 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		337458 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		411924 LCK_MOUSE (3-136): 1.79e-53: 184: 34.46		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Hs
		69208 A9UF07_HUMAN (4-134): 2.33e-49: 179: 36.23		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		292687 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		PTN23_MOUSE (412-788): 1.15e-09: 64.6: 10.73
+	Hs
		203198 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		411582 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		337335 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		411823 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25