HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22267732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 635
+	Hs
		411633 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		411632 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		411611 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		275157 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07
+	Hs
		275197 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		275158 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		411648 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		411544 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		411573 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		411545 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		411552 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		275161 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		411559 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		846473 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		338144 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		111146 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		I6L996_HUMAN (344-626): 1.14e-58: 210: 39.30
+	Hs
		337769 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		383699 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		383528 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		846446 BLK_HUMAN (3-153): 1.43e-54: 187: 28.66		BLK_HUMAN (162-267): 2.8e-29: 123: 32.43