HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.723

Property	Details
Experiments	27107012
Identification Methods	two hybrid, barcode fusion genetics two hybrid, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 870
+	Hs
		411645 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		337399 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		802537 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		337437 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		337597 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		412090 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840786 SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760481 SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840878 CD2AP_HUMAN (280-330): 4.65e-16: 81: 34.62		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		442794 HCK_HUMAN (192-329): 5.96e-16: 80.2: 21.43		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		433651 LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		522862 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840663 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		412411 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Mm
		760462 SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Hs
		983399 SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		522926 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		924499 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Rn
		599402 GRB2_RAT (274-326): 2.04e-13: 70.3: 38.89		DYN1_RAT (1-846): 0: 994: 78.57
+	Ce
		220206 SRC2_CAEEL (224-326): 6.19e-18: 86.4: 19.05		DYN1_CAEEL (3-823): 0: 899: 61.86