HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: TRI68 (Q6AZZ1)
E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)
Gene: TRIM68

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 485
+	Hs
		337563 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		TRI39_HUMAN (7-485): 2.34e-146: 430: 35.34
+	Hs
		802736 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		TRI39_HUMAN (7-485): 2.34e-146: 430: 35.34
+	Mm
		1143604 PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81		TRI27_MOUSE (1-485): 4.52e-140: 414: 34.57
+	Hs
		584954 GRAP_HUMAN (279-329): 6e-12: 66.1: 32.69		RO52_HUMAN (1-482): 2.52e-161: 467: 42.53
+	Hs
		412363 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		TRI39_HUMAN (7-485): 2.34e-146: 430: 35.34
+	Hs
		411977 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		TRI27_HUMAN (1-485): 3.84e-140: 414: 34.96
+	Hs
		411890 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		TRI35_HUMAN (3-481): 1.11e-102: 317: 23.64
+	Hs
		924879 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		TRI39_HUMAN (7-485): 2.34e-146: 430: 35.34
+	Hs
		442773 HCK_HUMAN (192-329): 5.96e-16: 80.2: 21.43		TRI27_HUMAN (1-485): 3.84e-140: 414: 34.96
+	Hs
		536781 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		TRI27_HUMAN (1-485): 3.84e-140: 414: 34.96
+	Hs
		433465 YES_HUMAN (198-327): 2.27e-21: 96.4: 21.97		TRIM5_HUMAN (3-483): 3.73e-119: 359: 33.20
+	Hs
		802723 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		TRI15_HUMAN (1-469): 3.88e-105: 323: 27.72
+	Hs
		523138 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		TRIM7_HUMAN (11-469): 6.78e-121: 364: 31.11
+	Hs
		523048 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		TRI50_HUMAN (1-477): 5.62e-117: 354: 25.31
+	Hs
		1078906 ITSN1_HUMAN (86-329): 9.9e-12: 68: 12.99		TRIM5_HUMAN (3-483): 3.73e-119: 359: 33.20
+	Hs
		523137 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		TRI15_HUMAN (1-469): 3.88e-105: 323: 27.72