HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: Q7Z783 (Q7Z783)
Protein sprouty homolog 2
Gene: Q7Z783

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 353
+	Hs
		208081 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		SPY2_HUMAN (1-312): 5.09e-132: 381: 98.72
+	Hs
		1192446 SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03		Q7Z783_HUMAN (1-353): 6.5e-164: 463: 100.00
+	Hs
		924668 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		Q7Z783_HUMAN (1-353): 6.5e-164: 463: 100.00
+	Mm
		1208609 PLCG2_MOUSE (9-329): 3.85e-35: 137: 16.81		SPY2_MOUSE (1-312): 1.92e-123: 359: 94.89
+	Hs
		208145 Q5JPT6_HUMAN (273-330): 1.35e-17: 85.7: 31.03		SPY2_HUMAN (1-312): 5.09e-132: 381: 98.72
+	Hs
		208177 SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03		SPY2_HUMAN (1-312): 5.09e-132: 381: 98.72
+	Hs
		208319 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		SPY1_HUMAN (1-309): 6.76e-113: 332: 50.94
+	Hs
		208125 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		SPY2_HUMAN (1-312): 5.09e-132: 381: 98.72
+	Hs
		208142 ITSN1_HUMAN (86-329): 9.9e-12: 68: 12.99		SPY2_HUMAN (1-312): 5.09e-132: 381: 98.72
+	Mm
		1246943 SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76		SPY2_MOUSE (1-312): 1.92e-123: 359: 94.89
+	Mm
		1141168 GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89		SPY2_MOUSE (1-312): 1.92e-123: 359: 94.89
+	Hs
		208390 SH3K1_HUMAN (273-330): 1.35e-17: 85.7: 31.03		SPY1_HUMAN (1-309): 6.76e-113: 332: 50.94
+	Hs
		208348 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		SPY1_HUMAN (1-309): 6.76e-113: 332: 50.94
+	Hs
		924846 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		SPY4_HUMAN (1-312): 1.22e-99: 298: 40.19
+	Mm
		1141172 GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89		SPY4_MOUSE (3-313): 1.16e-99: 298: 40.88
+	Mm
		1141169 GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89		SPY1_MOUSE (1-309): 2.28e-96: 290: 51.11
+	Hs
		412242 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		SPRE1_HUMAN (30-277): 2.72e-80: 253: 17.44
+	Hs
		208416 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		SPY3_HUMAN (39-314): 7.52e-91: 275: 43.82
+	Mm
		1113312 GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89		SPRY3_MOUSE (39-314): 3.52e-88: 268: 43.82
+	Hs
		433858 LYN_HUMAN (228-329): 1.46e-14: 76.4: 22.12		SPRE1_HUMAN (30-277): 2.72e-80: 253: 17.44