HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	11313918, 12496419
Identification Methods	affinity chromatography technology, pull down, two hybrid, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 833
+	Hs
		337520 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		581035 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		802687 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Mm
		292682 GRAP2_MOUSE (1-330): 1.83e-63: 205: 72.73		M4K1_MOUSE (1-810): 0: 815: 83.80
+	Hs
		412291 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		802792 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		412425 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		411606 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20
+	Hs
		411778 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MARK2_HUMAN (14-597): 8.02e-134: 419: 16.86
+	Hs
		282264 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		CDKL5_HUMAN (12-589): 4.98e-125: 400: 18.62
+	Hs
		337455 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		STK4_HUMAN (4-437): 2.54e-121: 376: 33.10
+	Hs
		580944 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		282266 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		CDKL5_HUMAN (12-589): 4.98e-125: 400: 18.62
+	Hs
		454830 FGR_HUMAN (203-329): 3.23e-19: 90.2: 21.54		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		412046 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Mm
		1113294 SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76		CDKL5_MOUSE (12-589): 1.92e-125: 401: 18.46
+	Hs
		681710 CSK_HUMAN (2-136): 2.34e-17: 84.3: 30.41		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		412163 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		STK4_HUMAN (4-437): 2.54e-121: 376: 33.10
+	Hs
		411790 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58
+	Mm
		949387 SH3K1_MOUSE (273-330): 1.5e-17: 85.3: 32.76		TNIK_MOUSE (11-296): 3.3e-64: 236: 42.57