HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 903
+	Hs
		125051 GRAP2_HUMAN (1-330): 1.74e-69: 221: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		412307 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1078893 ITSN1_HUMAN (86-329): 9.9e-12: 68: 12.99		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		337535 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		789085 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		125348 GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		337392 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		789045 ABL2_HUMAN (4-134): 2.67e-49: 178: 35.51		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		412081 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		433282 YES_HUMAN (198-327): 2.27e-21: 96.4: 21.97		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		522850 SRC_HUMAN (251-327): 1.41e-14: 76.2: 25.93		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		337496 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		802643 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		802865 CRKL_HUMAN (248-330): 9.75e-12: 66.8: 22.62		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		411864 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		454848 FGR_HUMAN (203-329): 3.23e-19: 90.2: 21.54		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71