HitPredict

Interactor 1: PR15A (O75807)
Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)
Gene: PPP1R15A

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	12016208, 29109149
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PP1c_bdg
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 674 Hs			1 327
+	Hs
		275400 PR15A_HUMAN (1-674): 0: 677: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		275382 PR15A_HUMAN (1-674): 0: 677: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		906487 PR15B_HUMAN (21-632): 4.23e-127: 394: 16.74		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		905954 PR15B_HUMAN (21-632): 4.23e-127: 394: 16.74		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737851 PR15B_HUMAN (21-632): 4.23e-127: 394: 16.74		PP1G_HUMAN (1-327): 0: 569: 86.89