HitPredict

Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.755

The method score is based on:

Property Details
Experiments 22973453, 15657067
Identification Methods pull down, anti bait coimmunoprecipitation
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005737 - cytoplasm
GO:0005925 - focal adhesion
GO:0007165 - signal transduction
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 825
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024