HitPredict

Interactor 1: EIF3G (O75821)
Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)
Gene: EIF3G

Interactor 2: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29228324, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 320 Hs			1 611
+	Hs
		516361 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		IF4B_HUMAN (1-611): 6.54e-98: 313: 100.00
+	Sc
		710350 EIF3G_YEAST (56-318): 1.08e-56: 186: 32.23		IF4B_YEAST (86-249): 9.35e-31: 126: 20.59
+	Zm
		8143 A0A1D6ELH4_MAIZE (54-320): 4.25e-36: 139: 15.33		A0A1D6ELH4_MAIZE (94-497): 7.01e-41: 159: 10.76
+	Sc
		376921 EIF3G_YEAST (56-318): 1.08e-56: 186: 32.23		PABP_YEAST (7-185): 1.17e-23: 107: 16.58
+	Hs
		474021 PAB4L_HUMAN (136-320): 1.67e-29: 117: 15.14		PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72
+	Hs
		516339 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		516495 PABP4_HUMAN (230-320): 6.63e-24: 104: 24.18		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		474019 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		PAB4L_HUMAN (6-198): 1.72e-27: 116: 13.40
+	Hs
		516484 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		516689 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		PABP3_HUMAN (54-547): 1.45e-22: 104: 11.07
+	Sc
		376562 PABP_YEAST (217-320): 7.71e-21: 94.9: 21.15		PABP_YEAST (7-185): 1.17e-23: 107: 16.58
+	Hs
		474034 PABP5_HUMAN (243-319): 7.67e-17: 82.1: 23.38		PAB4L_HUMAN (6-198): 1.72e-27: 116: 13.40
+	Hs
		1020249 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72
+	Hs
		516635 PABP5_HUMAN (243-319): 7.67e-17: 82.1: 23.38		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		958182 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		RBM3_HUMAN (98-241): 2.31e-22: 95.7: 24.83
+	Hs
		1119141 PABP5_HUMAN (243-319): 7.67e-17: 82.1: 23.38		PAP1L_HUMAN (49-389): 3.99e-23: 105: 10.28
+	Sc
		376663 PABP_YEAST (217-320): 7.71e-21: 94.9: 21.15		NSR1_YEAST (84-187): 1.96e-10: 65.3: 20.00