HitPredict

Interactor 1: EIF3G (O75821)
Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)
Gene: EIF3G

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 320 Hs			1 482
+	Hs
		275862 EIF3G_HUMAN (1-320): 2.71e-93: 281: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1031497 PABP4_HUMAN (230-320): 6.63e-24: 104: 24.18		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		516742 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Sc
		864602 EIF3G_YEAST (56-318): 1.08e-56: 186: 32.23		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		1030211 PABP4_HUMAN (230-320): 6.63e-24: 104: 24.18		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		516494 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1020248 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Mm
		957015 ELAV4_MOUSE (229-316): 7.56e-22: 96.4: 27.78		G3BP1_MOUSE (1-455): 2.96e-81: 261: 58.50
+	Hs
		680445 TIA1_HUMAN (101-316): 2.31e-16: 81: 20.36		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1030263 ELAV1_HUMAN (228-303): 5.65e-15: 76.4: 30.26		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Zm
		24464 A0A1D6K4S7_MAIZE (223-320): 5.14e-33: 128: 36.74		A0A1D6IIC3_MAIZE (7-467): 4.59e-61: 207: 23.11
+	Zm
		22429 A0A1D6I0G1_MAIZE (206-320): 9.22e-21: 94.9: 15.65		A0A1D6Q2L8_MAIZE (6-475): 6.16e-65: 218: 23.80
+	Sc
		376881 PABP_YEAST (217-320): 7.71e-21: 94.9: 21.15		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		1020262 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		1020256 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		1049508 PABP5_HUMAN (243-319): 7.67e-17: 82.1: 23.38		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		1031413 PABP4_HUMAN (230-320): 6.63e-24: 104: 24.18		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		516621 PABP1_HUMAN (230-320): 3.49e-24: 104: 26.37		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1020292 ELAV2_HUMAN (229-316): 7.55e-22: 96.4: 27.78		CELF5_HUMAN (293-418): 4.09e-17: 85.7: 17.83
+	Hs
		311347 ELAV1_HUMAN (228-303): 5.65e-15: 76.4: 30.26		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10