HitPredict

Interactor 1: PSD10 (O75832)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Gene: PSMD10

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

The method score is based on:

Property	Details
Experiments	18332869, 16023600, 17904523
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 5 others more... GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043066 - negative regulation of apoptotic process GO:0043518 - negative regulation of DNA damage response, signal transduction by p53 class mediator
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	226
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024