HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	34761192, 35384245, 17403676, 15212941
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 1210
+	Hs
		339110 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		272785 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339057 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338405 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339109 GGA2_HUMAN (2-511): 3.8e-55: 197: 16.80		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338478 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		159830 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		276988 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		277037 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		277152 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80
+	Hs
		277067 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		277010 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		277011 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		665303 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		434297 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		665436 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		665608 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Rn
		78228 B5DFM1_RAT (6-497): 1.18e-55: 195: 16.73		INSR_RAT (579-1032): 2.5e-106: 367: 23.66
+	Hs
		159843 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		435783 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47