HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 1114
+	Hs
		277002 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		276996 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		277004 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		276982 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		276985 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		601561 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		277074 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		277003 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		508131 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		609455 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		385279 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		277073 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		608072 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		241132 TOM1_HUMAN (1-444): 1.01e-80: 262: 17.68		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		1081556 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		508257 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		339110 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		272785 TM1L1_HUMAN (6-494): 3.07e-63: 215: 16.02		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		385689 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		608178 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89