HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 806
+	Hs
		609455 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		277011 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA3_HUMAN (1-786): 0: 641: 20.68
+	Hs
		277067 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA7_HUMAN (1-782): 0: 626: 21.22
+	Hs
		277036 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA5_HUMAN (1-777): 0: 622: 20.18
+	Hs
		277037 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA4_HUMAN (1-781): 0: 622: 20.78
+	Hs
		277152 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA6_HUMAN (1-774): 0: 600: 20.05
+	Hs
		277010 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		277012 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		EPHA8_HUMAN (1-771): 0: 593: 20.56
+	Hs
		665303 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		277073 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59
+	Hs
		277074 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51
+	Hs
		276985 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		385279 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		276988 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		RET_HUMAN (453-801): 9.71e-98: 330: 48.63
+	Hs
		276996 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		277002 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		277003 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Hs
		508131 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		601561 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		608072 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31