HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	10993906, 10899310
Identification Methods	enzymatic study, affinity chromatography technology, experimental interaction detection, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 1154
+	Hs
		238321 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Hs
		238425 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		936443 STAM1_MOUSE (1-513): 1.83e-114: 351: 53.96		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Mm
		936444 STAM1_MOUSE (1-513): 1.83e-114: 351: 53.96		JAK3_MOUSE (48-1154): 0: 761: 37.31
+	Hs
		277013 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		277031 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01
+	Hs
		277074 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK2_HUMAN (613-853): 8.97e-17: 87.8: 28.14
+	Hs
		276996 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		276985 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17
+	Hs
		277073 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		NTRK3_HUMAN (578-853): 5.4e-14: 79: 26.40
+	Hs
		277003 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR4_HUMAN (566-848): 2.44e-13: 76.6: 25.65
+	Hs
		277004 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR3_HUMAN (566-848): 5.13e-13: 75.5: 24.68
+	Hs
		277002 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		FGFR2_HUMAN (580-873): 9.52e-13: 74.7: 22.74
+	Hs
		854198 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01
+	Hs
		508131 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		385279 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		NTRK1_HUMAN (578-853): 2.13e-14: 80.1: 25.17
+	Hs
		1081556 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		NTRK3_HUMAN (578-853): 5.4e-14: 79: 26.40
+	Hs
		608072 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR4_HUMAN (566-848): 2.44e-13: 76.6: 25.65
+	Hs
		609455 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR3_HUMAN (566-848): 5.13e-13: 75.5: 24.68
+	Hs
		601561 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		FGFR2_HUMAN (580-873): 9.52e-13: 74.7: 22.74