HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.905

Property	Details
Experiments	25416956, 32296183, unassigned1304, 17235283
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 525 Hs			1 533
+	Hs
		1024144 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		275193 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		924534 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		292686 GRAP2_MOUSE (175-256): 1.61e-12: 70.5: 40.24		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		1141127 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		1264820 GGA1_HUMAN (2-516): 8.21e-63: 218: 14.50		TITIN_HUMAN (174-447): 1.53e-11: 69.6: 10.64
+	Hs
		203228 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		924670 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Mm
		292689 GRAP2_MOUSE (175-256): 1.61e-12: 70.5: 40.24		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Hs
		275217 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		924727 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Mm
		222321 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		O54737_MOUSE (52-523): 4.71e-33: 134: 19.88
+	Hs
		924632 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		203218 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		554292 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		924760 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		PRG4_HUMAN (53-459): 6.87e-09: 60.8: 10.39