Interactor 1: AL1L1 (O75891)
Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)
Gene: ALDH1L1

Interactor 2: AL1L2 (Q3SY69)
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2)
Gene: ALDH1L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Aldedh~Aldedh, Formyl_trans_C~Formyl_trans_C, Formyl_trans_C~Formyl_trans_N, Formyl_trans_N~Formyl_trans_N, PP-binding~PP-binding
Common GO terms GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0006730 - one-carbon metabolic process
GO:0006740 - NADPH regeneration
GO:0009058 - biosynthetic process
GO:0009258 - 10-formyltetrahydrofolate catabolic process
and 2 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 902
Hs

1 923
+ Dr
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc
+ Ec
+ Sc

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Last updated: 15 Jul 2024