HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34537242
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 2725
+	Hs
		277933 PIAS1_HUMAN (1-651): 0: 874: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261165 PIAS1_HUMAN (1-651): 0: 874: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		277910 PIAS1_HUMAN (1-651): 0: 874: 100.00		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211442 PIAS1_HUMAN (1-651): 0: 874: 100.00		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		278053 PIAS1_HUMAN (1-651): 0: 874: 100.00		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		521575 PIAS4_HUMAN (2-423): 0: 550: 51.42		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		278136 PIAS1_HUMAN (1-651): 0: 874: 100.00		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78