HitPredict

Interactor 1: RAD17 (O75943)
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
Gene: RAD17

Interactor 2: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12400013
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003689 - DNA clamp loader activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 681 Hs			1 1148
+	Hs
		278999 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47
+	Hs
		279002 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		279000 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26
+	Sc
		751312 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC1_YEAST (268-1148): 1.2e-125: 408: 29.95
+	Dm
		725339 Q9VX15_DROME (65-413): 2.23e-74: 245: 14.61		RFC1_DROME (175-1127): 2.34e-119: 395: 38.93
+	Hs
		722015 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		CTF18_HUMAN (293-1131): 2.29e-93: 323: 15.11
+	Sp
		293428 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC4_SCHPO (564-913): 1.57e-75: 255: 17.47
+	Sc
		751269 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC3_YEAST (572-928): 1.28e-76: 258: 21.25
+	Sp
		144044 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC3_SCHPO (565-918): 1.18e-73: 250: 19.72
+	Hs
		721934 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47
+	Sc
		772247 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC4_YEAST (583-908): 1.25e-73: 249: 20.53
+	Sc
		772422 RFC2_YEAST (82-429): 7e-76: 249: 15.64		CTF18_YEAST (561-1102): 9.39e-68: 245: 17.28
+	Hs
		722179 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		721936 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Zm
		75542 B4FQT5_MAIZE (88-449): 6.07e-77: 251: 14.99		B4FJC2_MAIZE (585-922): 1.9e-64: 224: 19.83
+	Hs
		722068 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26
+	Hs
		721933 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26
+	At
		1275801 RFC4_ARATH (86-429): 7.87e-79: 256: 14.61		RFC5_ARATH (580-837): 5.34e-42: 160: 20.53
+	Hs
		722022 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		ATAD5_HUMAN (494-707): 4.08e-36: 151: 25.96