HitPredict

Interactor 1: RAD17 (O75943)
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
Gene: RAD17

Interactor 2: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	28514442, 33961781, 14605214, 35271311, 14624239
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003689 - DNA clamp loader activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair and 1 others more... GO:0031389 - Rad17 RFC-like complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 681 Hs			1 340
+	Hs
		278999 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77
+	Hs
		279000 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35
+	Hs
		279003 RAD17_HUMAN (1-681): 0: 821: 100.00		RFC3_HUMAN (21-340): 6.47e-62: 202: 24.00
+	Hs
		722179 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00
+	Hs
		721936 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00
+	Sp
		144044 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC3_SCHPO (17-338): 1.43e-88: 271: 52.48
+	Hs
		721934 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77
+	Hs
		722068 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35
+	Hs
		721933 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35
+	Zm
		75542 B4FQT5_MAIZE (88-449): 6.07e-77: 251: 14.99		B4FJC2_MAIZE (18-340): 1.45e-85: 264: 56.75
+	At
		1275801 RFC4_ARATH (86-429): 7.87e-79: 256: 14.61		RFC5_ARATH (13-340): 2.2e-82: 256: 55.92
+	Sc
		751269 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC3_YEAST (9-334): 2.33e-83: 257: 49.10
+	Sp
		293428 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC4_SCHPO (3-330): 6.17e-79: 246: 35.46
+	Dm
		858480 Q9VX15_DROME (65-413): 2.23e-74: 245: 14.61		RFC2_DROME (6-334): 4.69e-83: 256: 34.85
+	Sp
		840133 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC2_SCHPO (6-331): 1.91e-77: 242: 37.91
+	Sc
		772247 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC4_YEAST (20-329): 1.41e-71: 226: 35.26
+	Sp
		294016 RAD17_SCHPO (42-529): 1.08e-75: 256: 23.61		RFC5_SCHPO (20-330): 9.74e-61: 200: 22.83
+	Hs
		722180 RFC1_HUMAN (31-495): 2.15e-71: 253: 14.04		RFC3_HUMAN (21-340): 6.47e-62: 202: 24.00
+	Hs
		721937 RFC4_HUMAN (52-407): 2.53e-76: 251: 15.47		RFC3_HUMAN (21-340): 6.47e-62: 202: 24.00
+	Sc
		747110 RFC2_YEAST (82-429): 7e-76: 249: 15.64		RFC5_YEAST (21-334): 1.99e-60: 199: 23.51