HitPredict

Interactor 1: DNJB5 (O75953)
DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)
Gene: DNAJB5

Interactor 2: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33957083
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding GO:0051087 - protein-folding chaperone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 348 Hs			1 646
+	Hs
		279280 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Hs
		279274 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		279284 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP72_HUMAN (2-646): 0: 940: 85.47
+	Hs
		504901 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		714088 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Hs
		564203 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		503463 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		636256 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Hs
		483809 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71B_HUMAN (1-646): 0: 948: 84.37
+	Hs
		503527 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		243275 DNJA2_HUMAN (2-347): 3.77e-127: 372: 34.37		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		681341 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Hs
		871816 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP72_HUMAN (2-646): 0: 940: 85.47
+	Hs
		564008 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		564015 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		243284 DNJA2_HUMAN (2-347): 3.77e-127: 372: 34.37		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		483773 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71B_HUMAN (1-646): 0: 948: 84.37
+	Hs
		483775 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HS71B_HUMAN (1-646): 0: 948: 84.37
+	Hs
		636289 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP72_HUMAN (2-646): 0: 940: 85.47
+	Hs
		681383 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HSP72_HUMAN (2-646): 0: 940: 85.47