HitPredict

Interactor 1: DNJB5 (O75953)
DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)
Gene: DNAJB5

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006986 - response to unfolded protein
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 348 Hs			1 840
+	Hs
		714449 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		636257 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		279330 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		320814 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		1267773 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		1123860 Q59E89_HUMAN (1-348): 9.84e-135: 388: 61.49		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		636386 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		279272 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		279280 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		279274 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		504901 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483809 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		714088 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		564203 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		503463 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483773 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		636256 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		503527 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483775 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		564008 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86