HitPredict

Interactor 1: DNJB5 (O75953)
DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)
Gene: DNAJB5

Interactor 2: HS105 (Q92598)
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)
Gene: HSPH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	33957083, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 348 Hs			1 858
+	Hs
		1267773 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS105_HUMAN (1-858): 0: 1004: 100.00
+	Hs
		1123860 Q59E89_HUMAN (1-348): 9.84e-135: 388: 61.49		HS105_HUMAN (1-858): 0: 1004: 100.00
+	Hs
		636386 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS105_HUMAN (1-858): 0: 1004: 100.00
+	Hs
		279281 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Hs
		320814 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS74L_HUMAN (1-858): 0: 953: 57.46
+	Hs
		714449 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Hs
		636257 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Hs
		279272 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		279280 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HS71L_HUMAN (586-716): 7.63e-31: 131: 19.70
+	Hs
		279274 DNJB5_HUMAN (1-348): 1.1e-147: 422: 100.00		HSP76_HUMAN (604-707): 8.59e-27: 118: 22.86
+	Hs
		504901 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		483809 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71B_HUMAN (586-707): 8.57e-31: 131: 21.14
+	Hs
		714088 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HS71L_HUMAN (586-716): 7.63e-31: 131: 19.70
+	Hs
		503463 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		564203 DNJB4_HUMAN (1-348): 4.71e-137: 394: 61.78		HSP76_HUMAN (604-707): 8.59e-27: 118: 22.86
+	Hs
		483773 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71B_HUMAN (586-707): 8.57e-31: 131: 21.14
+	Hs
		503527 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		636256 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HS71L_HUMAN (586-716): 7.63e-31: 131: 19.70
+	Hs
		483775 DNJA1_HUMAN (5-346): 1.18e-127: 373: 35.16		HS71B_HUMAN (586-707): 8.57e-31: 131: 21.14
+	Hs
		564008 DNJB1_HUMAN (1-346): 2.3e-130: 377: 59.71		HSP76_HUMAN (604-707): 8.59e-27: 118: 22.86