HitPredict

Interactor 1: FLOT1 (O75955)
Flotillin-1
Gene: FLOT1

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0016323 - basolateral plasma membrane GO:2000049 - positive regulation of cell-cell adhesion mediated by cadherin
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 1748
+	Hs
		159125 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		279584 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		279532 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		279647 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		279374 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61
+	Hs
		279650 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		279534 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		279631 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71
+	Mm
		1225129 PODO_MOUSE (3-216): 3.24e-16: 81.8: 19.54		UNC5B_MOUSE (1634-1718): 4.24e-11: 70.1: 43.53