HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 3097 Hs			1 758
+	Hs
		496988 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497586 SPTN4_HUMAN (89-1216): 3.71e-96: 351: 15.15		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		555250 SPTN1_RAT (186-2165): 8.78e-106: 383: 12.49		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94140 SPTN1_RAT (186-2165): 8.78e-106: 383: 12.49		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		496865 SPTB2_HUMAN (61-1626): 2.73e-78: 293: 12.52		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		164558 SPTN2_HUMAN (335-2015): 2.32e-70: 266: 12.03		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		582039 SPTN2_RAT (335-2015): 2.32e-69: 263: 12.20		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94264 SPTN2_RAT (335-2015): 2.32e-69: 263: 12.20		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		497258 SESD1_HUMAN (584-1100): 4.31e-19: 96.8: 15.68		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Dm
		54892 A1ZA72_DROME (2767-3080): 3.73e-44: 181: 38.87		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96
+	Dm
		54271 A1Z9I8_DROME (135-1487): 1.27e-31: 139: 11.70		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96