HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31478661
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Pkinase~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3097 Hs			1 191
+	Hs
		279854 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		279855 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		279851 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		224711 KALRN_HUMAN (53-3092): 0: 1984: 59.19		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		564519 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		925405 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		1045519 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		894178 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		925265 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		900648 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		893989 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		950981 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900456 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545364 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		892360 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		1183444 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		1045442 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Ce
		975576 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97
+	Ce
		104468 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		G5EBV3_CAEEL (2-191): 1e-81: 242: 58.95
+	Hs
		297809 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41