HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	10948190, 31871319
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Pkinase~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3097 Hs			1 193
+	Hs
		279854 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		279855 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		279850 TRIO_HUMAN (41-3097): 0: 2357: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		279853 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		224711 KALRN_HUMAN (53-3092): 0: 1984: 59.19		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900648 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925405 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900456 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		894178 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		925265 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		950981 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		893989 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545364 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892360 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915664 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120427 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Ce
		975576 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44
+	Ce
		104468 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52
+	Hs
		297809 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		120250 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98