HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	31871319, 32203420, 25065758, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~Ras, Pkinase~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0042995 - cell projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3097 Hs			1 191
+	Hs
		279854 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		279850 TRIO_HUMAN (41-3097): 0: 2357: 100.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		279851 TRIO_HUMAN (41-3097): 0: 2357: 100.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		224711 KALRN_HUMAN (53-3092): 0: 1984: 59.19		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		925405 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		925265 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		950981 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		894178 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		900648 ARHGP_HUMAN (1241-1632): 7.48e-120: 394: 34.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		545364 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		893989 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		900456 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		892360 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Hs
		564519 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Ce
		975576 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		RAC1_CAEEL (1-191): 4.3e-83: 245: 66.49
+	Ce
		104468 Q7KPP4_CAEEL (1017-2366): 6.5e-98: 354: 15.22		G5EBV3_CAEEL (2-191): 3.88e-79: 235: 60.00
+	Hs
		297812 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		297820 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		297809 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		297819 K0754_HUMAN (1-1887): 1.88e-84: 313: 11.11		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88