HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: ANFY1 (Q9P2R3)
Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)
Gene: ANKFY1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~I-set, Ank_2~I-set, Ank~Pkinase, Ank_2~Pkinase, Ank_2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3097 Hs			1 1169
+	Mm
		57869 KALRN_MOUSE (51-3092): 0: 2008: 59.43		ANK2_MOUSE (875-1138): 1.56e-54: 211: 18.58
+	Hs
		1205903 MF2L2_HUMAN (1281-1598): 6.87e-26: 119: 29.17		ANFY1_HUMAN (1-1169): 0: 717: 100.00
+	Hs
		965102 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		ANK2_HUMAN (2-789): 1.44e-127: 435: 18.85
+	Hs
		963292 SPTB2_HUMAN (61-1626): 2.73e-78: 293: 12.52		ANK2_HUMAN (2-789): 1.44e-127: 435: 18.85
+	Hs
		164604 SPTN2_HUMAN (335-2015): 2.32e-70: 266: 12.03		ANK2_HUMAN (2-789): 1.44e-127: 435: 18.85
+	Hs
		862028 DAPK1_HUMAN (2789-3051): 1.17e-56: 220: 41.70		ANK2_HUMAN (2-789): 1.44e-127: 435: 18.85
+	Hs
		965118 OBSCN_HUMAN (2268-3078): 2.27e-52: 208: 15.57		ANK2_HUMAN (2-789): 1.44e-127: 435: 18.85
+	Mm
		561172 SPTN1_MOUSE (186-2165): 7.22e-106: 383: 12.24		ANK2_MOUSE (875-1138): 1.56e-54: 211: 18.58
+	Hs
		1021399 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		ANK3_HUMAN (1-386): 1.03e-34: 147: 17.88
+	Hs
		556695 SPTB2_HUMAN (61-1626): 2.73e-78: 293: 12.52		ANK1_HUMAN (1-533): 2.33e-63: 239: 17.07
+	Mm
		82740 B9EKJ1_MOUSE (186-2165): 7.1e-105: 380: 12.32		ANK3_MOUSE (1-386): 4.26e-34: 144: 17.10
+	Hs
		506803 SPTB1_HUMAN (61-1488): 1.16e-72: 274: 12.61		ANK1_HUMAN (1-533): 2.33e-63: 239: 17.07
+	Hs
		1021458 SPTN4_HUMAN (89-1216): 3.71e-96: 351: 15.15		ANK3_HUMAN (1-386): 1.03e-34: 147: 17.88
+	Hs
		360612 SPTA1_HUMAN (220-1136): 4.04e-61: 236: 13.58		ANK1_HUMAN (1-533): 2.33e-63: 239: 17.07
+	Hs
		556706 OBSCN_HUMAN (2268-3078): 2.27e-52: 208: 15.57		ANK1_HUMAN (1-533): 2.33e-63: 239: 17.07
+	Hs
		963306 SPTB2_HUMAN (61-1626): 2.73e-78: 293: 12.52		ANK3_HUMAN (1-386): 1.03e-34: 147: 17.88
+	Hs
		164611 SPTN2_HUMAN (335-2015): 2.32e-70: 266: 12.03		ANK3_HUMAN (1-386): 1.03e-34: 147: 17.88
+	Hs
		166938 KCC4_HUMAN (2789-3082): 9.99e-45: 172: 36.36		ANR28_HUMAN (871-1156): 6.5e-49: 191: 19.86
+	Mm
		103598 Q3UGX2_MOUSE (162-1072): 1.02e-51: 205: 12.39		ANK3_MOUSE (1-386): 4.26e-34: 144: 17.10
+	Hs
		1083221 KCC4_HUMAN (2789-3082): 9.99e-45: 172: 36.36		ANR52_HUMAN (4-387): 7.32e-18: 91.8: 13.18